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Image Search Results
Journal: Pain Reports
Article Title: Cutaneous targets for topical pain medications in patients with neuropathic pain: individual differential expression of biomarkers supports the need for personalized medicine
doi: 10.1097/PR9.0000000000001121
Figure Lengend Snippet: Keratinocyte biomarker immunolabeling examples demonstrate the discreet variability among individual patients of the innervation pathology-matched PHN cohort. For every biomarker (A–I), at least one individual patient within the total cohort had significantly less ipsilateral labeling than contralateral (top plates), and at least one individual patient within the total cohort also had significantly more ipsilateral labeling than contralateral (bottom plates). A few TrpV1-positive small fiber IENF are also seen (G, white arrows). Mag bar = 50 µm for all images. IENF, intraepidermal nerve fibers; PHN, postherpetic neuralgia; TrpV1, transient receptor potential vanilloid 1.
Article Snippet: Deidentified
Techniques: Biomarker Discovery, Immunolabeling, Labeling
Journal: Pain Reports
Article Title: Cutaneous targets for topical pain medications in patients with neuropathic pain: individual differential expression of biomarkers supports the need for personalized medicine
doi: 10.1097/PR9.0000000000001121
Figure Lengend Snippet: Keratinocyte biomarker immunolabeling average pixel intensity (API) in contralateral (black) and ipsilateral (grey) biopsies from the total PHN patient cohort. Asterisks indicate a significant ( P < 0.05) within-patient difference between the contralateral (nonpain) and ipsilateral (pain) biopsy labeling. PHN, postherpetic neuralgia.
Article Snippet: Deidentified
Techniques: Biomarker Discovery, Immunolabeling, Labeling
Journal: Pain Reports
Article Title: Cutaneous targets for topical pain medications in patients with neuropathic pain: individual differential expression of biomarkers supports the need for personalized medicine
doi: 10.1097/PR9.0000000000001121
Figure Lengend Snippet: Keratinocyte biomarker API % difference of ipsilateral (pain) from contralateral (nonpain). Filled circles represent significant difference. The data show that for each of the biomarkers evaluated, a significant difference was seen in both directions among the total PHN cohort (n = 20). These data demonstrate the differential keratinocyte labeling for each biomarker, emphasizes the existence of patient subgroups within the enriched cohort, and highlights the potential for individualized topical treatment strategies based from skin biopsy analysis. API, average pixel intensity; PHN, postherpetic neuralgia.
Article Snippet: Deidentified
Techniques: Biomarker Discovery, Labeling
Journal: Pain Reports
Article Title: Cutaneous targets for topical pain medications in patients with neuropathic pain: individual differential expression of biomarkers supports the need for personalized medicine
doi: 10.1097/PR9.0000000000001121
Figure Lengend Snippet: Individual patient biomarker response codes were ordered to demonstrate the differential labeling among individual patients of the enriched PHN cohort. Based from the observed tissue biomarker expression patterns, potential individualized topical treatment regimen with appropriate effective compounds can be rationally advised. PHN, postherpetic neuralgia.
Article Snippet: Deidentified
Techniques: Biomarker Discovery, Labeling, Expressing